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N-Hydroxysuccinimide (NHS) is an organic compound with the formula (CH 2 CO) 2 NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis. It can be synthesized by heating succinic anhydride with hydroxylamine or hydroxylamine hydrochloride. [2]
Journal Citation Reports (JCR) is an annual publication by Clarivate. [1] It has been integrated with the Web of Science and is accessed from the Web of Science Core Collection. It provides information about academic journals in the natural and social sciences, including impact factors. JCR was originally published as a part of the Science ...
The impact factor relates to a specific time period; it is possible to calculate it for any desired period. For example, the JCR also includes a five-year impact factor, which is calculated by dividing the number of citations to the journal in a given year by the number of articles published in that journal in the previous five years. [14] [15]
It is the official journal of the International Water Resources Association and was established in 1972. The journal is published by Routledge in 8 issues per year and focuses on international water resources including science, technology, governance, management, and policy. [1] The editor-in-chief is James E. Nickum (International Water ...
The Journal of Sustainable Development of Energy, Water and Environment Systems is a quarterly peer-reviewed open-access scientific journal covering sustainability studies. [1] The editor-in-chief is Neven Duić ( University of Zagreb ).
In protein synthesis (such as Fmoc solid-state synthesizers), the N-terminus is often used as the attachment site on which the amino acid monomers are added. To enhance the electrophilicity of carboxylate group, the negatively charged oxygen must first be "activated" into a better leaving group. DCC is used for this purpose.
Common uses for this carbodiimide include peptide synthesis, protein crosslinking to nucleic acids, but also in the preparation of immunoconjugates. EDC is often used in combination with N-hydroxysuccinimide (NHS) for the immobilisation of large biomolecules. Recent work has also used EDC to assess the structure state of uracil nucleobases in RNA.
Analyst is a biweekly peer-reviewed scientific journal covering all aspects of analytical chemistry, bioanalysis, and detection science. It is published by the Royal Society of Chemistry and the editor-in-chief is Norman Dovichi (University of Notre Dame). [1] The journal was established in 1877 by the Society for Analytical Chemistry.