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The general structure of a guanidine. Guanidines are a group of organic compounds sharing a common functional group with the general structure (R 1 R 2 N)(R 3 R 4 N)C=N−R 5. The central bond within this group is that of an imine, and the group is related structurally to amidines and ureas.
Delocalization of charge in guanidinium group of l-Arginine The amino acid side-chain of arginine consists of a 3-carbon aliphatic straight chain, the distal end of which is capped by a guanidinium group, which has a p K a of 13.8, [ 39 ] and is therefore always protonated and positively charged at physiological pH.
Petrunkin and Petrunkin (1927, 1928) appear to be the first who studied the binding of GnHCl to gelatin and a mixture of thermally denatured protein from brain extract. . Greenstein (1938, 1939), however, appears to be the first to discover the high denaturing action of guanidinium halides and thiocyanates in following the liberation of sulfhydryl groups in ovalbumin and other proteins as a ...
The general structure of a guanidine Subcategories. This category has the following 9 subcategories, out of 9 total. ... Guanidinium compounds (6 P) H ...
The reactivity of a functional group can be modified by other functional groups nearby. Functional group interconversion can be used in retrosynthetic analysis to plan organic synthesis. A functional group is a group of atoms in a molecule with distinctive chemical properties, regardless of the other atoms in the molecule. The atoms in a ...
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.
Guanidine nitrate is the chemical compound with the formula [C(NH 2) 3]NO 3.It is a colorless, water-soluble salt. It is produced on a large scale and finds use as precursor for nitroguanidine, [1] fuel in pyrotechnics and gas generators.
Galega officinalis (French lilac) was used in diabetes treatment for centuries. [5] In the 1920s, guanidine compounds were discovered in Galega extracts. Animal studies showed that these compounds lowered blood glucose levels.