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Upstream extracellular signaling transduce a variety of intracellular cascades. [1] Receptors and ligands are common upstream signaling molecules that dictate the downstream elements of the signal pathway. A plethora of different factors affect which ligands bind to which receptors and the downstream cellular response that they initiate.
Therapeutic cell manufacturing processes can be separated into upstream processes and downstream processes. The upstream process is defined as the entire process from early cell isolation and cultivation, to cell banking and culture expansion of the cells until final harvest (termination of the culture and collection of the live cell batch).
Vertical integration is the degree to which a firm owns its upstream suppliers and its downstream buyers. The differences depend on where the firm is placed in the order of the supply chain. There are three varieties of vertical integration: backward (upstream) vertical integration, forward (downstream) vertical integration, and balanced (both ...
The downstream is made up of chemical and refining operations. These businesses can be just as volatile as the upstream, but often in a counter cyclical way since oil and natural gas are key ...
The relative positions of structures along strands of nucleic acid, including genes and various protein binding sites, are usually noted as being either upstream (towards the 5′-end) or downstream (towards the 3′-end). (See also upstream and downstream.) Directionality is related to, but different from, sense.
This means the upstream and downstream areas of the molecule may change depending on which gene is used as the reference. The terms upstream and downstream are sometimes also applied to a polypeptide sequence, where upstream refers to a region N-terminal and downstream to residues C-terminal of a reference point.
Each segment has its own dynamics: In the upstream and downstream arenas, performance tends to be more volatile, based on fluctuating commodity prices, while the toll-takers of the midstream are ...
Upstream and downstream can refer to: Molecular biology. Upstream and downstream (DNA), determining relative positions on DNA; Upstream and downstream (transduction) ...