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A sequela (UK: / s ɪ ˈ k w iː l ə /, [1] US: / s ɪ ˈ k w ɛ l ə /; [2] [3] usually used in the plural, sequelae /-iː /) is a pathological condition resulting from a disease, injury, therapy, or other trauma. Derived from the Latin word meaning "sequel", it is used in the medical field to mean a complication or condition following a ...
Knowledge of the most common and severe complications of a disease, procedure, or treatment allows for prevention and preparation for treatment if they should occur. Complications are not to be confused with sequelae, which are residual effects that occur after the acute (initial, most severe) [1] phase of an illness or injury. Sequelae can ...
Terminable cause-effect relation between the diseases; One disease resulting from complications of another; Pleiotropy [66] The factors responsible for the development of comorbidity can be chronic infections, inflammations, involutional and systematic metabolic changes, iatrogenesis, social status, ecology and genetic susceptibility.
The distinction between adverse and nonadverse effects is a major undertaking when a new drug is developed and tested before marketing it. This is done in toxicity studies to determine the nonadverse effect level (NOAEL). These studies are used to define the dosage to be used in human testing (phase I), as well as to calculate the maximum ...
Myocardial infarction complications may occur immediately following a myocardial infarction (heart attack) (in the acute phase), or may need time to develop (a chronic problem). After an infarction, an obvious complication is a second infarction, which may occur in the domain of another atherosclerotic coronary artery, or in the same zone if ...
Post-polio syndrome (PPS, poliomyelitis sequelae) is a group of latent symptoms of poliomyelitis (polio), occurring at about a 25–40% rate (latest data greater than 80%). They are caused by the damaging effects of the viral infection on the nervous system and typically occur 15 to 30 years after an initial acute paralytic attack.
Secondary injury can result from complications of the injury. [1] These include ischemia (insufficient blood flow); cerebral hypoxia (insufficient oxygen in the brain); hypotension (low blood pressure); cerebral edema (swelling of the brain); changes in the blood flow to the brain; and raised intracranial pressure (the pressure within the skull ...
Signs and symptoms of PTS in the leg may include: [1] pain (aching or cramping) heaviness; itching or tingling; swelling (edema) varicose veins; brownish or reddish skin discoloration