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Phenethylamine is sold as a dietary supplement for purported mood and weight loss-related therapeutic benefits; however, in orally ingested phenethylamine, a significant amount is metabolized in the small intestine by monoamine oxidase B (MAO-B) and then aldehyde dehydrogenase (ALDH), which converts it to phenylacetic acid. [5]
It appears to cross the blood–brain barrier less efficiently than L-phenylalanine, and so a small amount of an ingested dose of D-phenylalanine is excreted in the urine without penetrating the central nervous system. [24] L-Phenylalanine is an antagonist at α 2 δ Ca 2+ calcium channels with a K i of 980 nM. [25]
[1] [2] [3] In mice, high levels of Lac-Phe in the blood cause a decrease of food intake [1] and in humans, its production has been shown to correlate with adipose tissue loss during an endurance exercise intervention. [4] In mammals it is created from -lactate and L-phenylalanine by the cytosol nonspecific dipeptidase (CNDP2) protein. [5]
Weight loss medications like Contrave (a combination of naltrexone and bupropion) block the reward pathways that make it tempting to binge eat, but there are side effects.
"Upping your vegetable intake is a great place to start when trying to lose weight or get healthier in general," says Jessica Ball, M.S., RD, a registered dietitian and EatingWell's nutrition ...
Weight loss is a personal for everyone, so it’s hard to say that you’ll drop pounds just by having more protein and fiber in your diet. However, eating both may help you to feel fuller for longer.
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