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Medulloblastoma is the second-most frequent brain tumor in children after pilocytic astrocytoma [37] and the most common malignant brain tumor in children, comprising 14.5% of newly diagnosed brain tumors. [38] In adults, medulloblastoma is rare, comprising fewer than 2% of CNS malignancies. [39]
The most common brain tumor types in children (0–14) are: pilocytic astrocytoma, malignant glioma, medulloblastoma, neuronal and mixed neuronal-glial tumors, and ependymoma. [106] In children under 2, about 70% of brain tumors are medulloblastomas, ependymomas, and low-grade gliomas.
Pilocytic astrocytoma (and its variant pilomyxoid astrocytoma) is a brain tumor that occurs most commonly in children and young adults (in the first 20 years of life). They usually arise in the cerebellum, near the brainstem, in the hypothalamic region, or the optic chiasm, but they may occur in any area where astrocytes are present, including the cerebral hemispheres and the spinal cord.
A central nervous system tumor (CNS tumor) is an abnormal growth of cells from the tissues of the brain or spinal cord. [1] CNS tumor is a generic term encompassing over 120 distinct tumor types. [ 2 ]
Pleomorphic xanthoastrocytoma (PXA) is a brain tumor that occurs most frequently in children and teenagers. At Boston Children's Hospital, the average age at diagnosis is 12 years. [1] Pleomorphic xanthoastrocytoma usually develops within the supratentorial region (the area of the brain located above the tentorium cerebelli).
Brain tumors are the most common type of solid tumors to affect the pediatric population. [3] In particular, medulloblastoma is the most common of them, and constitutes about 20% of all the malignant pediatric brain tumors, classified as a primitive neuroectodermal tumor (PNET) of the cerebellum. [4]
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