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Slow continuous ultrafiltration (SCUF) is an artificial method which approximately mimics the ultrafiltration function of the kidneys. SCUF is a continuous renal replacement therapy (CRRT) generally used to remove fluid from fluid overloaded patients with acute kidney failure.
Before implementing continuous renal replacement therapy (CRRT), acute renal failure (ARF) in critically ill, multiple organ failure patients was managed by intermittent hemodialysis and the mortality rate was very high. [4] Hemodialysis is effective in clearance and ultrafiltration, but it has deleterious effects on hemodynamic stability. [5]
Schematic of semipermeable membrane during hemodialysis, where blood is red, dialysing fluid is blue, and the membrane is yellow. Kidney dialysis [a] is the process of removing excess water, solutes, and toxins from the blood in people whose kidneys can no longer perform these functions naturally.
The AquaFlexFlow UF 500 Plus blood circuit is designed for single use. It is utilized for continuous ultrafiltration therapy in adult and pediatric patients with fluid overload who are unresponsiv.
The study, conducted by Viswanath R. Chinta, MD, Dr. John L. Jefferies, MD, MBA, MPH, and fellow researchers, is titled “Outcomes of Ultrafiltration in community-based hospitals” and sought to evaluate and validate the role of a newly implemented Aquadex ultrafiltration therapy program in a community hospital setting. The study analyzed ...
Ultrafiltration (UF) is a variety of membrane filtration in which forces such as pressure or concentration gradients lead to a separation through a semipermeable membrane. Suspended solids and solutes of high molecular weight are retained in the so-called retentate, while water and low molecular weight solutes pass through the membrane in the ...
Hemofiltration is sometimes used in combination with hemodialysis, when it is termed hemodiafiltration. Blood is pumped through the blood compartment of a high flux dialyzer, and a high rate of ultrafiltration is used, so there is a high rate of movement of water and solutes from blood to dialysate that must be replaced by substitution fluid that is infused directly into the blood line.
[3] Glucose is the most commonly used osmotic agent and different concentrations of glucose in the dialysis fluid affect the ultrafiltration. Icodextrin is a high molecular weight glucose polymer developed as an alternative osmotic agent with slower absorbtion from the peritoneal cavity, facilitating better ultrafiltration. It is recommended ...