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A BLAST variant called MegaBLAST indexes 4 databases to speed up alignments. [9] BLAT can extend on multiple perfect and near-perfect matches (default is 2 perfect matches of length 11 for nucleotide searches and 3 perfect matches of length 4 for protein searches), while BLAST extends only when one or two matches occur close together. [1] [9]
While BLAST does a linear search, BLAT relies on k-mer indexing the database, and can thus often find seeds faster. [22] Another software alternative similar to BLAT is PatternHunter . Advances in sequencing technology in the late 2000s has made searching for very similar nucleotide matches an important problem.
It makes use of the BLAST [5] algorithm to identify similar sequences to then transfers existing functional annotation from yet characterised sequences to the novel one. The functional information is represented via the Gene Ontology (GO), a controlled vocabulary of functional attributes.
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Distributed with the latest version of BLAST, this wrapper facilitates parallelization of the algorithm on modern hybrid architectures with many nodes and many cores within each node. [2] Protein: Burdyshaw CE, Sawyer S, Horton MD, Brook RG, Rekapalli B: 2017 CS-BLAST: Sequence-context specific BLAST, more sensitive than BLAST, FASTA, and SSEARCH.
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Blast or The Blast may refer to: Explosion , a rapid increase in volume and release of energy in an extreme manner Detonation , an exothermic front accelerating through a medium that eventually drives a shock front