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  2. Protein S deficiency - Wikipedia

    en.wikipedia.org/wiki/Protein_S_deficiency

    [1] [11] [12] Testing for protein S deficiency should be delayed if there are causes for acquired deficiency or interfering factors. [13] The initial assay for congenital protein S deficiency should be the free protein S antigen assay. If the level is low, total protein S antigen assay can be performed to differentiate between type I and type ...

  3. Protein S - Wikipedia

    en.wikipedia.org/wiki/Protein_S

    Protein S (also known as PROS) is a vitamin K -dependent plasma glycoprotein synthesized in the liver. In the circulation, Protein S exists in two forms: a free form and a complex form bound to complement protein C4b-binding protein (C4BP). In humans, protein S is encoded by the PROS1 gene. [5][6] Protein S plays a role in coagulation.

  4. Sticky platelet syndrome - Wikipedia

    en.wikipedia.org/wiki/Sticky_platelet_syndrome

    It can present in conjunction with protein S deficiency and factor V Leiden. [8] It is not currently known if sticky platelet syndrome is a distinct condition, or if it represents part of the presentation of a more well characterized coagulation disorder. SPS has not been widely studied [9] and is not widely known. [10]

  5. Kell antigen system - Wikipedia

    en.wikipedia.org/wiki/Kell_antigen_system

    The Kell antigen system (also known as the Kell–Cellano system) is a human blood group system, that is, a group of antigens on the human red blood cell surface which are important determinants of blood type and are targets for autoimmune or alloimmune diseases which destroy red blood cells. The Kell antigens are K, k, Kpa, Kpb, Jsa and Jsb. [1]

  6. Thrombophilia - Wikipedia

    en.wikipedia.org/wiki/Thrombophilia

    An ultrasound image demonstrating a blood clot in the left common femoral vein. Thrombophilia (sometimes called hypercoagulability or a prothrombotic state) is an abnormality of blood coagulation that increases the risk of thrombosis (blood clots in blood vessels). [1][2] Such abnormalities can be identified in 50% of people who have an episode ...

  7. von Willebrand disease - Wikipedia

    en.wikipedia.org/wiki/Von_Willebrand_disease

    Von Willebrand disease (VWD) is the most common hereditary blood-clotting disorder in humans. An acquired form can sometimes result from other medical conditions. [1] It arises from a deficiency in the quality or quantity of von Willebrand factor (VWF), a multimeric protein that is required for platelet adhesion.

  8. Glanzmann's thrombasthenia - Wikipedia

    en.wikipedia.org/wiki/Glanzmann's_thrombasthenia

    Hematology. Glanzmann's thrombasthenia is an abnormality of the platelets. [2] It is an extremely rare coagulopathy (bleeding disorder due to a blood abnormality), in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for fibrinogen. As a result, no fibrinogen bridging of platelets to ...

  9. Evans syndrome - Wikipedia

    en.wikipedia.org/wiki/Evans_syndrome

    Evans syndrome. Evans syndrome is an autoimmune disease in which an individual's immune system attacks their own red blood cells and platelets, the syndrome can include immune neutropenia. [1][2] These immune cytopenias may occur simultaneously or sequentially. [1][3] Its overall phenotype resembles a combination of autoimmune hemolytic anemia ...

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