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Atropine is an antidote for cholinergic toxicity from organophosphates and nerve agents and acute treatment of bradyarrhythmias. Medications with anticholinergic properties include antidepressants, antihistamines, antiparkinson drugs, antipsychotics, antispasmodics, and mydriatics.
Learn about the mechanisms, presentation, and management of anticholinergic toxidrome, a common emergency department condition. Find out the list of anticholinergic medications and plants, and how to treat anticholinergic overdose.
Learn about the causes, symptoms, diagnosis and treatment of anticholinergic poisoning, a common and potentially life-threatening condition. Find out how physostigmine can help distinguish anticholinergic from sympathomimetic toxidromes and how to manage agitation and combined anticholinergic and sodium channel blocker toxicity.
Learn about the mechanisms, presentation, and management of anticholinergic toxicity, a common emergency department problem. Find out the list of anticholinergic substances, the summary table for emergency management, and the references for this topic.
Learn how to manage anticholinergic toxicity with physostigmine or rivastigmine, two acetylcholinesterase inhibitors that can reverse central anticholinergic effects. Find out about physostigmine shortages, rivastigmine alternatives, and Anticholium® importation.
Learn how to recognize and treat anticholinergic toxicity, a common cause of poisoning. Find out when to use physostigmine, the antidote, and how to avoid complications such as seizures and...
Learn about the causes, symptoms, and treatment of anticholinergic syndrome, a condition caused by the inhibition of cholinergic neurotransmission. Find out when to use activated charcoal,...
Treatment is aggressive supportive care, plus targeted therapy for cholinergic toxicity: atropine followed by an available oxime such as pralidoxime. Decontamination and personal protective equipment must be used to prevent further absorption of the agent by the patient and harm to caregivers.
By the end of this simulation case, learners will be able to: 1) describe the classic clinical presentation of anticholinergic toxicity, 2) discuss common medications and substances that may lead to anticholinergic toxicity, 3) recognize the electrocardiogram (ECG) findings in anticholinergic toxicity that require specific therapy, and 4 ...
Learn what anticholinergic toxicity is, how it occurs, and what drugs or plants can cause it. Find out the common symptoms, diagnosis, and treatment of this condition that affects acetylcholine levels in the brain.