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The loop electrosurgical excision procedure (LEEP) is one of the most commonly used approaches to treat high grade cervical dysplasia (CIN II/III, HGSIL) and early stage cervical cancer discovered on colposcopic examination. In the UK, it is known as large loop excision of the transformation zone (LLETZ).
'hollow, womb, vagina' + skopos 'look at') is a medical diagnostic procedure to visually examine the cervix as well as the vagina and vulva using a colposcope. [1] The main goal of colposcopy is to prevent cervical cancer by detecting and treating precancerous lesions early.
The cause of CIN is chronic infection of the cervix with HPV, especially infection with high-risk HPV types 16 or 18. It is thought that the high-risk HPV infections have the ability to inactivate tumor suppressor genes such as the p53 gene and the RB gene, thus allowing the infected cells to grow unchecked and accumulate successive mutations, eventually leading to cancer.
A precancerous condition is a condition, tumor or lesion involving abnormal cells which are associated with an increased risk of developing into cancer. [1] [2] [3] Clinically, precancerous conditions encompass a variety of abnormal tissues with an increased risk of developing into cancer.
Cervical conization refers to an excision of a cone-shaped portion of tissue from the mucous membrane of the cervix. Conization is used for diagnostic purposes as part of a biopsy and for therapeutic purposes to remove pre-cancerous cells ( cervical intraepithelial neoplasia ) or early stage cervical cancer .
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The formal name of this operation is radical vaginal trachelectomy (RVT) and also known as the Dargent operation and radical trachelectomy. [citation needed]The word radical is used as, in addition to the cervix (like in radical hysterectomies), the parametria (tissue adjacent to the cervix) and vaginal cuff (the end of the vagina close to the cervix) are also excised as a part of the ...