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Cotrimoxazole: This is an antibiotic which incorporates sulphonamides and trimethoprim. It covers a broad spectrum of activity and in dentistry, is often used where there are clear signs and indications of bacterial infection that is sensitive to cotrimoxazole. This is determined by bacteriological sensitivity tests. [11]
Clinical trials have confirmed its efficacy, with or without adjunctive doxycycline; although, co-trimoxazole alone seems preferable. [38] [39] [40] Pertussis (whooping cough) No: No: No: One cochrane review supports its efficacy in preventing the spread of pertussis. [41] Shigellosis: Yes: Yes: No: Generally accepted treatment for shigellosis ...
Wide range of infections; penicillin used for streptococcal infections, syphilis, and Lyme disease: Gastrointestinal upset and diarrhea; Allergy with serious anaphylactic reactions; Brain and kidney damage (rare) Same mode of action as other beta-lactam antibiotics: disrupt the synthesis of the peptidoglycan layer of bacterial cell walls ...
Antibiotic use was not associated with an increased risk of cognitive impairment and dementia in healthy older adults, according to a recent study.
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I'd like to add in the fact that in Canada co-trimoxazole is considered a first-line agent for skin and wound infections in patients who have a demonstrated true allergy to penicillin, but I can't find an online reference that isn't behind a paywall. Does anyone have one? --Charlene 14:31, 17 July 2007 (UTC)
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