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They can be designed to specifically target cancer biomarkers, allowing for highly sensitive and accurate detection of cancer cells or molecules associated with cancer. Gene therapy: Nanocarriers, such as lipid nanoparticles or polymer nanoparticles, can deliver therapeutic genes to cancer cells. This approach aims to modify the genetic makeup ...
Reduction Sensitive Nanoparticles are used as nanomedicines for drug delivery. As nanocarriers, RSNP can be loaded with drugs for disease therapeutics. [18] This is commonly observed in the use of tumor and cancer treatments. Cancer cells create reducing environments that are used for RSNP activation.
Nanoparticles of natural polymers such as chitosan are commonly used adjuvants in modern vaccine formulations. [64] Ceria nanoparticles appear very promising for both enhancing vaccine responses and mitigating inflammation, as their adjuvanticity can be adjusted by modifying parameters such as size, crystallinity, surface state, and stoichiometry.
In prostate cancer, the androgen receptor (AR) plays a critical role in progression of the cancer. Lipid nanoparticles (LNPs) are being considered for delivering siRNA to silence AR. The most effective LNP to be found in vivo contains an ionizable cationic lipid 2,2-dilinoleyl-4-(2-dimethylaminoethyl)-[1,3]-dioxolane (DLin-KC2-DMA). [4]
It can be directed to the location of cancer cells with sustained release behavior. Studies have also been done on gold nanoparticle responses to local near-infrared (NIR) light as a stimuli for drug release. In one study, gold nanoparticles functionalized with double-stranded DNA encapsulated with drug molecules, were irradiated with NIR light.
In photothermal cancer therapy, many gold nanoparticle molecules are used in each test and they must all be uniform in size. Including PEG coating, the nanoparticles measured to be ~130 nm in diameter. [1] Gold nanoparticles that act as drug delivery systems in conjugation with chemotherapeutic drugs typically range in size from 10 to 100 nm. [2]
In polymer chemistry, in situ polymerization is a preparation method that occurs "in the polymerization mixture" and is used to develop polymer nanocomposites from nanoparticles. There are numerous unstable oligomers ( molecules ) which must be synthesized in situ (i.e. in the reaction mixture but cannot be isolated on their own) for use in ...
Polymer-drug conjugates are drug molecules held in polymer molecules, which act as the delivery system for the drug. Polymer drugs have passed multidrug resistance (MDR) testing and hence may become a viable treatment for endocrine-related cancers. A cocktail of pendant drugs could be delivered by water-soluble polymer platforms.