Search results
Results from the WOW.Com Content Network
Postsynaptic potentials undergo spatial and temporal summation due to their graded nature. [9] Spatial summation: When inputs are received simultaneously at nearby synapses, their postsynaptic potentials combine. Multiple excitatory inputs combine resulting in greater membrane depolarization (more positive).
In neuroscience, an excitatory postsynaptic potential (EPSP) is a postsynaptic potential that makes the postsynaptic neuron more likely to fire an action potential. This temporary depolarization of postsynaptic membrane potential, caused by the flow of positively charged ions into the postsynaptic cell, is a result of opening ligand-gated ion ...
End plate potentials (EPPs) are the voltages which cause depolarization of skeletal muscle fibers caused by neurotransmitters binding to the postsynaptic membrane in the neuromuscular junction. They are called "end plates" because the postsynaptic terminals of muscle fibers have a large, saucer-like appearance.
Depolarization, a deviation from a neuron's resting membrane potential towards its threshold potential, increases the likelihood of an action potential and normally occurs with the influx of positively charged sodium (Na +) ions into the postsynaptic cell through ion channels activated by neurotransmitter binding.
Depolarization is the process by which the membrane potential becomes less negative, facilitating the generation of an action potential. [6] For this rapid change to take place within the interior of the cell, several events must occur along the plasma membrane of the cell.
This inward flow of sodium leads to a short term depolarization of the postsynaptic neuron and an EPSP. While a single depolarization of this kind may not have much of an effect on the postsynaptic neuron, repeated depolarizations caused by high frequency stimulation can lead to EPSP summation and to surpassing the threshold potential. [9]
Excitatory post-synaptic potentials (EPSPs) depolarize the membrane and move the potential closer to the threshold for an action potential to be generated. Inhibitory postsynaptic potentials (IPSPs) hyperpolarize the membrane and move the potential farther away from the threshold, decreasing the likelihood of an action potential occurring. [2]
Most research has been focused on the AMPARs and the NMDARs. When glutamate binds to AMPARs located on the postsynaptic membrane, they permit a mixed flow of Na + and K + to cross the cells membrane, causing a depolarization of the postsynaptic membrane. This localized depolarization is called an excitatory postsynaptic potential (EPSP).