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Phospholipase D is an important player in many physiological processes, including membrane trafficking, cytoskeletal reorganization, receptor-mediated endocytosis, exocytosis, and cell migration. [8] Through these processes, it has been further implicated in the pathophysiology of multiple diseases : in particular the progression of Parkinson's ...
A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze: Phospholipase A Phospholipase A 1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering).
Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.
Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. [ 5 ] [ 6 ] PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, it has no known catalytic function similar to PLD1 or PLD2 .
5338 18806 Ensembl ENSG00000129219 ENSMUSG00000020828 UniProt O14939 P97813 RefSeq (mRNA) NM_001243108 NM_002663 NM_008876 NM_001302475 NM_001302476 NM_001361935 RefSeq (protein) NP_001230037 NP_002654 NP_001289404 NP_001289405 NP_032902 NP_001348864 Location (UCSC) Chr 17: 4.81 – 4.82 Mb Chr 11: 70.43 – 70.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase D2 is an ...
Phospholipase D 1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, [5] [6] though analogues are found in plants, fungi, prokaryotes, and even viruses. [ 7 ] History
Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene. [5] [6] Many proteins are tethered to the extracellular face of eukaryotic plasma membranes by a glycosylphosphatidylinositol (GPI) anchor. The GPI-anchor is a glycolipid found on many blood cells.
N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) is an enzyme that catalyzes the release of N-acylethanolamine (NAE) from N-acyl-phosphatidylethanolamine (NAPE). This is a major part of the process that converts ordinary lipids into chemical signals like anandamide and oleoylethanolamine .