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The complex pathophysiology of preeclampsia begins with abnormal placental development, endothelial dysfunction, and immunologic aberrations, possibly related to genetic susceptibility.
Pathophysiology. Preeclampsia can be broadly categorized into 2 subtypes: early-onset ( or placental) and late-onset (or maternal) preeclampsia. Both appear to have distinguished etiologies and phenotypes. Regarding the early-onset type, the defective placenta is attributed to the development of preeclampsia.
Abstract. The incidence of pre-eclampsia ranges from 3% to 7% for nulliparas and 1% to 3% for multiparas. Pre-eclampsia is a major cause of maternal mortality and morbidity, preterm birth, perinatal death, and intrauterine growth restriction. Unfortunately, the pathophysiology of this multisystem disorder, characterized by abnormal vascular ...
Although commonly portrayed as a distinct entity, pre-eclampsia, at least its early onset variety, is just one in a spectrum of complications of pregnancy that share a common pathophysiology centered upon disordered placentation.
Abstract. Preeclampsia is a hypertensive disorder of pregnancy. It affects 2% to 8% of pregnancies worldwide and causes significant maternal and perinatal morbidity and mortality. Hypertension and proteinuria are the cornerstone of the disease, though systemic organ dysfunction may ensue.
Preeclampsia usually begins after 20 weeks of pregnancy in women whose blood pressure had previously been in the standard range. Left untreated, preeclampsia can lead to serious — even fatal — complications for both the mother and baby. Early delivery of the baby is often recommended.
Preeclampsia is persistent high blood pressure that happens during pregnancy or after giving birth. It is potentially serious and its complications, such as liver and kidney damage, can threaten the life of mother and baby.
Preeclampsia is a pregnancy-specific syndrome characterized by the onset of hypertension and proteinuria or hypertension and end-organ dysfunction with or without proteinuria after 20 weeks of gestation (table 1).
Pre-eclampsia is a complication of pregnancy that is associated with substantial maternal and fetal morbidity and mortality. The disease presents with new-onset hypertension and often proteinuria in the mother, which can progress to multi-organ dysfunction, including hepatic, renal and cerebral disease, if the fetus and placenta are not delivered.
The focus of clinical management of preeclampsia are prevention of maternal morbidity by aggressive treatment of hypertensive emergency, maternal seizure prevention in severe pre-eclampsia, and limiting injury to the fetus.