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Urea transporter 2 is a protein that in humans is encoded by the SLC14A2 gene. [5] [6] Function ... the renal tubular urea transporter, UT2 , ...
A urea transporter is a membrane transport protein, transporting urea. Humans and other mammals have two types of urea transport proteins, UT-A and UT-B. The UT-A proteins are important for renal urea handling and are produced by alternative splicing of the SLC14A2 gene. [1] Urea transport in the kidney is regulated by vasopressin. [2]
Renal urea handling is the part of renal physiology that deals with the reabsorption and secretion of urea.Movement of large amounts of urea across cell membranes is made possible by urea transporter proteins.
The collecting duct system is the final component of the kidney to influence the body's electrolyte and fluid balance. In humans, the system accounts for 4–5% of the kidney's reabsorption of sodium and 5% of the kidney's reabsorption of water. At times of extreme dehydration, over 24% of the filtered water may be reabsorbed in the collecting ...
A simple means of estimating renal function is to measure pH, blood urea nitrogen, creatinine, and basic electrolytes (including sodium, potassium, chloride, and bicarbonate). As the kidney is the most important organ in controlling these values, any derangement in these values could suggest renal impairment.
Kidd antigens are located on a red blood cell urea transporter (human urea transporter 11- HUT11 or UT-B1). [8] As red blood cells approach the renal medulla (where there is a high concentration of urea), the urea transporter allows for rapid uptake of urea and prevents cell shrinkage in the hypertonic environment of the medulla. [5]
Examples of approved drugs that act as renal tubular transport inhibitors include: Probenecid: This is an inhibitor of the organic anion transport system, particularly OAT1 and OAT3. [2] [1] It is used clinically to increase the systemic concentrations of certain drugs by reducing their renal excretion. [4]
Ultrafiltration (kidney) Urea transporter; Urine flow rate; Urine sodium; V. Vasopressin ... This page was last edited on 2 January 2014, at 20:55 (UTC).