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A high degree of tolerance often occurs in people who use benzodiazepine long term, especially if they take high doses, which can lead to benzodiazepine dependence. The benzodiazepine withdrawal syndrome seen in chronic high dose benzodiazepine users is similar to that seen in therapeutic low dose users but of a more severe nature.
Doses as high as 15–20 mg/kg are taken by some recreational users. A single case study suggests that the antidote to dextromethorphan overdose is naloxone, administered intravenously. [17] In addition to producing PCP-like mental effects, high doses may cause a false-positive result for PCP and opiates in some drug tests. [9] [18]
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol [29] by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform, and ethyl ether.
In this select population who are naive to and overdose solely on a benzodiazepine, it can be considered. [53] Due to its short half life, the duration of action of flumazenil is usually less than 1 hour, and multiple doses may be needed. [48] When flumazenil is indicated the risks can be reduced or avoided by slow dose titration of flumazenil ...
"Because I Got High" is a comedy hip hop song by American rapper Afroman from the 2000 album of the same name. The lyrics of the song humorously describe how cannabis use is degrading the narrator's quality of life. [ 1 ]
The high usually lasts from five to ten minutes, [4] [11] after which time dopamine levels in the brain plummet, leaving the user feeling depressed and low. [4] When (powder) cocaine is dissolved and injected , the absorption into the bloodstream is at least as rapid as the absorption of the drug which occurs when crack cocaine is smoked, [ 11 ...
Jenkem is a purported inhalant and hallucinogen created from fermented human waste.In the mid-1990s, it was reported to be a popular street drug among Zambian youth, created by placing feces and urine in a bottle or a bucket, sealing it with a balloon or lid and leaving it to ferment in the sun; afterwards they would inhale the gases generated.
Cetacaine is a topical anesthetic that contains the active ingredients benzocaine (14%), butamben (2%), and tetracaine hydrochloride (2%). Cetacaine also contains small amounts of benzalkonium chloride at 0.5% and 0.005% of cetyl dimethyl ethyl ammonium bromide all in a bland water-soluble base. [1]