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Thyroid hormones act on nearly every cell in the body. They act to increase the basal metabolic rate, affect protein synthesis, help regulate long bone growth (synergy with growth hormone) and neural maturation, and increase the body's sensitivity to catecholamines (such as adrenaline) by permissiveness. [12]
3,5-T 2 is an active thyroid hormone. It stimulates the TR-beta receptor for thyroid hormones and thus increases energy expenditure. [1] [2] It has agonistic (thyromimetic) effects at myocardial tissue and pituitary, which results in 3,5-T 2 suppressing TSH release.
The pituitary gland (or hypophysis) is an endocrine gland about the size of a pea and weighing 0.5 grams (0.018 oz) in humans. It is a protrusion off the bottom of the hypothalamus at the base of the brain, and rests in a small, bony cavity (sella turcica) covered by a dural fold (diaphragma sellae).
At the cellular level, T 3 is the body's more active and potent thyroid hormone. [2] T 3 helps deliver oxygen and energy to all of the body's cells, its effects on target tissues being roughly four times more potent than those of T 4. [2] Of the thyroid hormone that is produced, just about 20% is T 3, whereas 80% is produced as T 4.
Thyroid hormones are important for normal development. [28] They increase the growth rate of young people, [29] and cells of the developing brain are a major target for the thyroid hormones T 3 and T 4. Thyroid hormones play a particularly crucial role in brain maturation during fetal development and first few years of postnatal life [28]
It is the primary form of thyroid hormone found in the blood and acts as a prohormone of the more active thyroid hormone, triiodothyronine (T 3). [1] Thyroxine and its active metabolites are essential for regulating metabolic rate , supporting heart and muscle function , promoting brain development , and maintaining bone health .
The following is a list of hormones found in Humans. Spelling is not uniform for many hormones. Spelling is not uniform for many hormones. For example, current North American and international usage uses [ citation needed ] estrogen and gonadotropin, while British usage retains the Greek digraph in oestrogen and favours the earlier spelling ...
The thyroid hormones increase the rate of cellular metabolism, and include thyroxine (T4) and triiodothyronine (T3). Secretion is stimulated by the thyroid-stimulating hormone, secreted by the anterior pituitary. When thyroid levels are high, there is negative feedback that decreases the amount of Thyroid-stimulating hormone secreted.