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  2. Equianalgesic - Wikipedia

    en.wikipedia.org/wiki/Equianalgesic

    An equianalgesic chart can be a useful tool, but the user must take care to correct for all relevant variables such as route of administration, cross tolerance, half-life and the bioavailability of a drug. [5] For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the ...

  3. Extended-release morphine - Wikipedia

    en.wikipedia.org/wiki/Extended-release_morphine

    According to a Cochrane review in 2013, extended-release morphine as an opioid replacement therapy for people with heroin addiction or dependence confers a possible reduction of opioid use and with fewer depressive symptoms but overall more adverse effects when compared to other forms of long-acting opioids. The length of time in treatment was ...

  4. Hydromorphone - Wikipedia

    en.wikipedia.org/wiki/Hydromorphone

    Patients with renal abnormalities must exercise caution when dosing hydromorphone. In those with renal impairment, the half-life of hydromorphone may increase to as much as 40 hours. The typical half-life of intravenous hydromorphone is 2.3 hours. [48] Peak plasma levels usually occur between 30 and 60 minutes after oral dosing. [49]

  5. Methadone - Wikipedia

    en.wikipedia.org/wiki/Methadone

    The metabolic half-life is 8 to 59 hours (approximately 24 hours for opioid-tolerant people, and 55 hours for opioid-naive people), as opposed to a half-life of 1 to 5 hours for morphine. [12] The length of the half-life of methadone allows for the exhibition of respiratory depressant effects for an extended duration of time in opioid-naive people.

  6. Opioids were the most common cause of fatal poisoning of ...

    www.aol.com/news/opioids-were-most-common-cause...

    But opioids accounted for a growing share of the substances responsible for poisonings between 2005 and 2018: Whereas 24% of the various substances that killed children in 2005 were opioids, they ...

  7. Naloxone - Wikipedia

    en.wikipedia.org/wiki/Naloxone

    The mean serum half-life has been shown to range from 30 to 81 minutes, shorter than the average half-life of some opiates, necessitating repeat dosing if opioid receptors must be stopped from triggering for an extended period. Naloxone is primarily metabolized by the liver.

  8. In the fentanyl crisis, infants and toddlers become ... - AOL

    www.aol.com/news/fentanyl-crisis-infants...

    In California, there were 11 fentanyl-related deaths for children younger than 5 in 2023, according to preliminary data. In Bakersfield, a 2-year-old died from acute fentanyl toxicity, and his ...

  9. Oxymorphone - Wikipedia

    en.wikipedia.org/wiki/Oxymorphone

    Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. [6]