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Dr. Grinspoon – a primary care physician and educator at Massachusetts General Hospital and an instructor at Harvard Medical School – wrote about the pros and cons of ketamine use for ...
These techniques facilitate the use of propofol, etomidate, ketamine, and other intravenous anesthetic agents. During or after TIVA, patients may be subjected to an elevated risk of anesthesia awareness, hyperalgesia and neurotoxicity. [2] Considering these risks, special consideration is given to obese, elderly and pediatric patients ...
While S-ketamine is more effective as an analgesic and anesthetic through NMDA receptor antagonism, R-ketamine produces longer-lasting effects as an antidepressant. [ 19 ] The optical rotation of a given enantiomer of ketamine can vary between its salts and free base form.
Cannabis use during pregnancy should be avoided. [80] There is no known safe dose of cannabis while pregnant and use of cannabis may lead to birth defects, pre-term birth, or low birth weight. [80] Tetrahydrocannabinol (THC), an active ingredient in cannabis, can both cross the placenta and accumulates in high concentrations in breast milk. [81]
Ketamine comes with a “unique set of risks, both to the individual but also to society,” including the potential for drug abuse and unknown effects of frequent use, especially at higher levels.
You may have also heard of ketamine therapy, which uses ketamine, a drug that was originally used as an animal anesthetic, administered in a clinical setting to improve mental health symptoms.
Esketamine, sold under the brand names Spravato (for depression) and Ketanest (for anesthesia) among others, [10] [12] is the S(+) enantiomer of ketamine. [5] [13] It is a dissociative hallucinogen drug used as a general anesthetic and as an antidepressant for treatment of depression.
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