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Phospholipase D is an important player in many physiological processes, including membrane trafficking, cytoskeletal reorganization, receptor-mediated endocytosis, exocytosis, and cell migration. [8] Through these processes, it has been further implicated in the pathophysiology of multiple diseases : in particular the progression of Parkinson's ...
A phospholipase is an enzyme that hydrolyzes phospholipids [1] into fatty acids and other lipophilic substances. There are four major classes, termed A, B, C, and D, which are distinguished by the type of reaction which they catalyze: Phospholipase A Phospholipase A 1 – cleaves the sn-1 acyl chain (where sn refers to stereospecific numbering).
Glycosylphosphatidylinositol phospholipase D (EC 3.1.4.50, GPI-PLD, glycoprotein phospholipase D, phosphatidylinositol phospholipase D, phosphatidylinositol-specific phospholipase D) is an enzyme with systematic name glycoprotein-phosphatidylinositol phosphatidohydrolase.
5338 18806 Ensembl ENSG00000129219 ENSMUSG00000020828 UniProt O14939 P97813 RefSeq (mRNA) NM_001243108 NM_002663 NM_008876 NM_001302475 NM_001302476 NM_001361935 RefSeq (protein) NP_001230037 NP_002654 NP_001289404 NP_001289405 NP_032902 NP_001348864 Location (UCSC) Chr 17: 4.81 – 4.82 Mb Chr 11: 70.43 – 70.45 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase D2 is an ...
14756 Ensembl ENSG00000112293 ENSMUSG00000021340 UniProt P80108 O70362 RefSeq (mRNA) NM_001503 NM_177483 NM_008156 RefSeq (protein) NP_001494 n/a Location (UCSC) Chr 6: 24.42 – 24.5 Mb Chr 13: 25.13 – 25.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phosphatidylinositol-glycan-specific phospholipase D is an enzyme that in humans is encoded by the GPLD1 gene. Many proteins ...
Phospholipase D3, also known as PLD3, is a protein that in humans is encoded by the PLD3 gene. [ 5 ] [ 6 ] PLD3 belongs to the phospholipase D superfamily because it contains the two HKD motifs common to members of the phospholipase D family, however, it has no known catalytic function similar to PLD1 or PLD2 .
Phosphatidylethanols (PEth) are a group of phospholipids formed only in the presence of ethanol via the action of phospholipase D (PLD). [1] It accumulates in blood and is removed slowly, making it a useful biomarker for alcohol consumption. [2] PEth is also thought to contribute to the symptoms of alcohol intoxication. [3]
5337 18805 Ensembl ENSG00000075651 ENSMUSG00000027695 UniProt Q13393 Q9Z280 RefSeq (mRNA) NM_001130081 NM_002662 NM_001164056 NM_008875 NM_001368667 RefSeq (protein) NP_001123553 NP_002653 n/a Location (UCSC) Chr 3: 171.6 – 171.81 Mb Chr 3: 27.99 – 28.19 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Phospholipase D 1 (PLD1) is an enzyme that in humans is encoded by the PLD1 ...