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Glutathione peroxidase (GPx) (EC 1.11.1.9) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. [2] The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to ...
Glutathione peroxidase 1, also known as GPx1, is an enzyme that in humans is encoded by the GPX1 gene on chromosome 3. [5] This gene encodes a member of the glutathione peroxidase family. Glutathione peroxidase functions in the detoxification of hydrogen peroxide , and is one of the most important antioxidant enzymes in humans.
Glutathione peroxidase 2 is an enzyme that in humans is encoded by the GPX2 gene. [5] [6] [7]This gene is a member of the glutathione peroxidase family encoding a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract.
75512 Ensembl ENSG00000281185 ENSG00000198704 ENSMUSG00000004341 UniProt P59796 Q91WR8 RefSeq (mRNA) NM_182701 NM_145451 RefSeq (protein) NP_874360 NP_663426 Location (UCSC) Chr 6: 28.5 – 28.53 Mb Chr 13: 21.5 – 21.5 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 6 (GPx-6) is an enzyme that in humans is encoded by the GPX6 gene. This gene product belongs ...
Glutathione peroxidases use glutathione as an electron donor and are active with both hydrogen peroxide and organic hydroperoxide substrates. Gpx1 , Gpx2 , Gpx3, and Gpx4 have been shown to be selenium -containing enzymes, whereas Gpx6 is a selenoprotein in humans with cysteine-containing homologues in rodents.
69590 Ensembl ENSG00000164294 ENSMUSG00000021760 UniProt Q8TED1 Q9D7B7 RefSeq (mRNA) NM_001008397 NM_001306197 NM_001306198 NM_001306201 NM_027127 RefSeq (protein) NP_001008398 NP_001293126 NP_001293127 NP_001293130 NP_081403 Location (UCSC) Chr 5: 55.16 – 55.17 Mb Chr 13: 113.18 – 113.18 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutathione peroxidase 8 (GPx-8) is an ...
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