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Lanreotide, sold under the brand name Somatuline among others, is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid syndrome. It is a long-acting analogue of somatostatin , like octreotide .
Another peptide known to self-assemble is the octapeptide Lanreotide. This compound is a synthetic analogue of the peptide hormone somatostatin and it is used to treat acromegaly [6] (a condition where the body produced too much growth hormone). In water, Lanreotide self-assembles into monodisperse liquid crystalline nanotubes. The nanotubes ...
Somatostatin analogs (i.e. Octreotide, Lanreotide) are used to stimulate these receptors, and thus to inhibit further tumor proliferation. [28] Paltusotine is a promising selective oral once-daily nonpeptide SSTR2 agonist in development as long-term maintenance therapy of acromegaly in adults.
This represented a 53% reduction in risk of disease progression or death with lanreotide based on a hazard ratio of .47. [86] Lanreotide is the first and only FDA approved antitumor therapy demonstrating a statistically significant progression-free survival benefit in a combined population of patients with GEP-NETS. [citation needed]
Octreotide is used for the treatment of growth hormone producing tumors (acromegaly and gigantism), when surgery is contraindicated, pituitary tumors that secrete thyroid-stimulating hormone (thyrotropinoma), [citation needed] diarrhea and flushing episodes associated with carcinoid syndrome, and diarrhea in people with vasoactive intestinal peptide-secreting tumors ().
For the use in PRRT TOC was coupled with the chelator DOTA, to form the octapeptide DOTA-TOC (D). PRRT radiopharmaceuticals are constructed with three components; the radionuclide, chelator, and somatostatin analogue (peptide). The radionuclide delivers the actual therapeutic effect (or emission, such as photons, for imaging). The chelator is ...
Pegvisomant, sold under the brand name Somavert, is a growth hormone receptor antagonist used in the treatment of acromegaly. [1] [2] [3] It is primarily used if the pituitary gland tumor causing the acromegaly cannot be controlled with surgery or radiation, and the use of somatostatin analogues is unsuccessful, but is also effective as a monotherapy. [4]
Abbreviations are used in the list as follows: ... lanreotide ; lansoprazole ; Lantidra; Lantrisul; Lantus (Sanofi-Aventis) lap-lax. lapaquistat acetate ;