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  2. Rifampicin - Wikipedia

    en.wikipedia.org/wiki/Rifampicin

    Rifampicin is the most powerful known inducer of the hepatic cytochrome P450 enzyme system, including isoenzymes CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP3A4, CYP3A5, and CYP3A7. [42] It increases metabolism of many drugs [ 43 ] and as a consequence, can make them less effective, or even ineffective, by decreasing their levels. [ 44 ]

  3. Management of tuberculosis - Wikipedia

    en.wikipedia.org/wiki/Management_of_tuberculosis

    Management of tuberculosis refers to techniques and procedures utilized for treating tuberculosis (TB), or simply a treatment plan for TB.. The medical standard for active TB is a short course treatment involving a combination of isoniazid, rifampicin (also known as Rifampin), pyrazinamide, and ethambutol for the first two months.

  4. Rifamycin - Wikipedia

    en.wikipedia.org/wiki/Rifamycin

    Rifampin rapidly kills fast-dividing bacilli strains as well as "persisters" cells, which remain biologically inactive for long periods of time that allow them to evade antibiotic activity. [7] In addition, rifabutin and rifapentine have both been used against tuberculosis acquired in HIV-positive patients.

  5. Tuberculosis - Wikipedia

    en.wikipedia.org/wiki/Tuberculosis

    If a tuberculosis infection does become active, it most commonly involves the lungs (in about 90% of cases). [14] [49] Symptoms may include chest pain and a prolonged cough producing sputum. About 25% of people may not have any symptoms (i.e., they remain asymptomatic). [14]

  6. Multidrug-resistant tuberculosis - Wikipedia

    en.wikipedia.org/wiki/Multidrug-resistant...

    Treatment of MDR-TB requires treatment with second-line drugs, usually four or more anti-TB drugs for a minimum of 6 months, and possibly extending for 18–24 months if rifampin resistance has been identified in the specific strain of TB with which the patient has been infected. [9]

  7. Biological half-life - Wikipedia

    en.wikipedia.org/wiki/Biological_half-life

    So, for example, digoxin has a half-life (or t ⁠ 1 / 2 ⁠) of 24–36 h; this means that a change in the dose will take the best part of a week to take full effect. For this reason, drugs with a long half-life (e.g., amiodarone , elimination t ⁠ 1 / 2 ⁠ of about 58 days) are usually started with a loading dose to achieve their desired ...

  8. Rifapentine - Wikipedia

    en.wikipedia.org/wiki/Rifapentine

    Rifapentine, sold under the brand name Priftin, is an antibiotic used in the treatment of tuberculosis. [2] In active tuberculosis it is used together with other antituberculosis medications. [2]

  9. Isoniazid - Wikipedia

    en.wikipedia.org/wiki/Isoniazid

    It is possible that isoniazid may decrease the serum levels of ketoconazole after long-term treatment. This is seen with the simultaneous use of rifampin, isoniazid, and ketoconazole. [49] Isoniazid may increase the amount of phenytoin in the body. The doses of phenytoin may need to be adjusted when given with isoniazid. [50] [51]

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