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He recognised the role of allergy in the pathogenesis of Henoch-Schonlein purpura, hence the understanding of the allergic component in HSP. [34] William Osler is also the first to recognise the underlying allergic mechanism of HSP. [35] In 2012, the International Chapel Hill Consensus Conference Nomenclature of Vasculitides renamed HSP IgA ...
Henoch–Schönlein purpura (HSP) - Often considered a systemic form of IgA nephropathy, Henoch–Schönlein purpura (HSP) is a systemic small-vessel vasculitis that is characterized by deposition of IgA antibody immune complexes in different key areas throughout the body.
Schönlein, Schoenlein may refer to: . Johann Lukas Schönlein (1793, Bamberg – 1864), a German professor of medicine . Henoch–Schönlein purpura (HSP, German: Purpura Schönlein-Henoch, also known as "anaphylactoid purpura", "purpura rheumatica", and "Schönlein–Henoch purpura)
Immune complex glomerulonephritis, as seen in Henoch-Schönlein purpura; this is an example of IgA involvement in a nephropathy. The reaction can take hours, days, or even weeks to develop, depending on whether or not there is immunological memory of the precipitating antigen. Typically, clinical features emerge a week following initial antigen ...
Eduard Heinrich Henoch (June 16, 1820 Berlin – August 26, 1910) was a German physician. He taught at the Berlin University (1868–1894). Henoch was of Jewish descent, and was the nephew of Moritz Heinrich Romberg .
Purpura (/ ˈ p ɜːr p jʊər ə / [1]) is a condition of red or purple discolored spots on the skin that do not blanch on applying pressure. The spots are caused by bleeding underneath the skin secondary to platelet disorders, vascular disorders, coagulation disorders, or other causes. [ 2 ]
There are numerous causes of palpable purpura, such as autoimmune diseases, drug reactions, vaccinations, and infections.The most common infectious causes are N. gonorrhoeae, S. aureus, and N. meningitides, however palpable purpura has also been caused by Mycoplasma spp., Rickettsiae, Mycobacterium, and very rarely by Treponema pallidum, Brucella spp., Yersinia, Campylobacter, and Bartonella.
Schönlein described purpura rheumatica (Schönlein's disease) an allergic non-thrombopenic purpura rash that became known as Henoch–Schönlein purpura, though now known as IgA vasculitis. [3] [4] He also discovered the parasitic cause of ringworm or favus (Trichophyton schönleinii). [5]