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In analytical chemistry, the detection limit, lower limit of detection, also termed LOD for limit of detection or analytical sensitivity (not to be confused with statistical sensitivity), is the lowest quantity of a substance that can be distinguished from the absence of that substance (a blank value) with a stated confidence level (generally 99%).
A calibration curve plot showing limit of detection (LOD), limit of quantification (LOQ), dynamic range, and limit of linearity (LOL).. In analytical chemistry, a calibration curve, also known as a standard curve, is a general method for determining the concentration of a substance in an unknown sample by comparing the unknown to a set of standard samples of known concentration. [1]
The normal distribution is NOT assumed nor required in the calculation of control limits. Thus making the IndX/mR chart a very robust tool. Thus making the IndX/mR chart a very robust tool. This is demonstrated by Wheeler using real-world data [ 4 ] , [ 5 ] and for a number of highly non-normal probability distributions.
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The control limits are set at three standard deviations on either side of the process mean, and are known as the upper control limit (UCL) and lower control limit (LCL) respectively. [2] If the process data plotted on the control chart remains within the control limits over an extended period, then the process is said to be stable. [2] [3]
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An example of a Levey–Jennings chart with upper and lower limits of one and two times the standard deviation. A Levey–Jennings chart is a graph that quality control data is plotted on to give a visual indication whether a laboratory test is working well. The distance from the mean is measured in standard deviations.