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ER-positive is one of the Receptor statuses identified in the classification of breast cancer.Receptor status was traditionally considered by reviewing each individual receptor (ER, PR, her2) in turn, but newer approaches look at these together, along with the tumor grade, to categorize breast cancer into several conceptual molecular classes [1] that have different prognoses [2] and may have ...
Breast cancers typically fall into one of four subtypes, based on whether the cancer cells have an overabundance of the HER2 gene, and/or receptors for estrogen (ER-positive), progesterone (PR ...
HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.
The anti-ER (SP1) antibody targets the ER alpha protein (ERα) located in the nucleus of ER-positive cells. [6] The anti-ER (SP1) antibody's response is a useful indication of the progression, management, and prediction of therapy outcome of breast cancer.
Triple-negative breast cancer. Triple-negative breast cancer acts aggressively, grows quickly, spreads further and is more likely to return, the American Cancer Society says. It often occurs in ...
Different molecular subtypes of breast cancer have also been described, which loosely align with receptor status: Luminal A (ER and/or PR positive; HER2 negative) Luminal B (ER and/or PR positive; HER2 positive) HER2-enriched (ER/PR negative; HER2 positive) Basal like (triple negative). [6]
MammaPrint has been prospectively, clinically validated for use in early stage (I and II) breast cancer patients regardless of estrogen receptor (ER) or Human Epidermal Growth Factor Receptor 2 (HER2) status, with a tumor size ≤ 5.0 cm, and 0-3 positive lymph nodes (LN0-1), with no special specifications for N1mi pathology.
Trastuzumab deruxtecan is the first approved therapy by the US Food and Drug Administration (FDA) targeted to people with the HER2-low breast cancer subtype. [4] DNA-based classification. Understanding the specific details of a particular breast cancer may include looking at the cancer cell DNA or RNA by several different laboratory approaches ...
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