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Three main changes are seen in the mechanism of Raynaud's phenomenon which are reduced blood flow, blood vessel constriction, and neurogenic, inflammatory, and immune responses. It is induced by mental stress and a cold atmosphere. In all cases, the primary cause is an underlying hyperactivation of the sympathetic nervous system. [19]
As blood is pumped through the body, the valves within the veins prevent the blood from flowing backwards. After extensive, prolonged standing, these valves can become weak and eventually fail. When this happens, blood is no longer being prevented from flowing backward. Gravity will pull the blood back into an individual's legs, ankles and feet.
Chronic venous insufficiency (CVI) is when the valves in the leg veins don’t work right and inappropriately allow blood to flow backward, back into the legs/feet from the effects of gravity.
Gangrene itself happens when the tissue loses blood flow and becomes deprived of oxygen and nutrients. Without proper blood supply, cells in the affected area start dying, leading to decay. There are different types of gangrene, including dry, wet, and gas gangrene, depending on the underlying cause and the conditions of the tissue.
The increase in pulse pressure may result in increased damage to blood vessels in target organs such as the brain or kidneys. [23] [24] This effect may be exaggerated if the increase in arterial stiffness results in reduced wave reflection and more propagation of the pulsatile pressure into the microcirculation. [23]
It reduces vasoconstriction and increases blood flow to limb. It aids in healing and giving relief from pain of ischemic ulcers. [1] Bypass can sometimes be helpful in treating limbs with poor perfusion secondary to this disease. Use of vascular growth factor and stem cell injections have been showing promise in clinical studies.
The underlying mechanism is believed to involve constriction of blood vessels resulting in insufficient blood flow to the feet. [1] Diagnosis is based on symptoms and examination. [1] Prevention involves keeping the feet warm, dry, and clean. [1] After the condition has occurred, pain medications may be required during the gradual rewarming ...
Flammer syndrome is a described clinical entity comprising a complex of clinical features caused mainly by dysregulation of the blood supply. It was previously known as vascular dysregulation. [1] It can manifest in many symptoms, such as cold hands and feet, and is often associated with low blood pressure.
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