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Burkholderia pseudomallei [a] (also known as Pseudomonas pseudomallei) is a Gram-negative, bipolar, aerobic, motile rod-shaped bacterium. [2] It is a soil-dwelling bacterium endemic in tropical and subtropical regions worldwide, particularly in Thailand and northern Australia. [ 3 ]
Burkholderia mallei and B. pseudomallei have a history of being on a list of potential biological warfare agents. The Centers for Disease Control and Prevention classifies B. mallei as a category B critical biological agent. [7] As a result, research regarding B. mallei may only be done in biosafety level 3 facilities in the US and internationally.
Burkholderia is a genus of Pseudomonadota whose pathogenic members include the Burkholderia cepacia complex, which attacks humans and Burkholderia mallei, responsible for glanders, a disease that occurs mostly in horses and related animals; Burkholderia pseudomallei, causative agent of melioidosis; and Burkholderia cepacia, an important pathogen of pulmonary infections in people with cystic ...
Melioidosis is an infectious disease caused by a gram-negative bacterium called Burkholderia pseudomallei. [1] Most people exposed to B. pseudomallei experience no symptoms; however, those who do experience symptoms have signs and symptoms that range from mild, such as fever and skin changes, to severe with pneumonia, abscesses, and septic shock that could cause death. [1]
It includes some pathogenic species, such as Burkholderia mallei and Burkholderia pseudomallei (melioidosis). [5] This family was found to be enriched in scale-eating pupfish (Cyprinodon desquamator) guts, even after being fed a common laboratory diet, suggesting it may aid in scale-digestion (Heras and Martin 2022).
Treatment of such infections can be difficult due to multiple antibiotic resistance, [4] and in the United States, there was an increase in MDRPA (Multidrug-resistant Pseudomonas aeruginosa) resistant to ceftazidime, ciprofloxacin, and aminoglycosides, from 0.9% in 1994 to 5.6% in 2002. [5]
The overarching goal of Pathema is to provide a core resource that will accelerated scientific progress towards understanding, detection, diagnosis and treatment of diseases caused by six clades of Category A-C pathogens (Bacillus anthracis, Clostridium botulinum, Burkholderia mallei, Burkholderia pseudomallei, Clostridium perfringens, and ...
Burkholderia thailandensis is a nonfermenting motile, Gram-negative bacillus that occurs naturally in soil. It is closely related to Burkholderia pseudomallei , but unlike B. pseudomallei , it only rarely causes disease in humans or animals.