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The inner ear (internal ear, auris interna) is the innermost part of the vertebrate ear. In vertebrates, the inner ear is mainly responsible for sound detection and balance. [1] In mammals, it consists of the bony labyrinth, a hollow cavity in the temporal bone of the skull with a system of passages comprising two main functional parts: [2]
There are two types of hair cells specific to the auditory system; inner and outer hair cells. Inner hair cells are the mechanoreceptors for hearing: they transduce the vibration of sound into electrical activity in nerve fibers, which is transmitted to the brain. Outer hair cells are a motor structure.
3D model of cochlea and semicircular canals. The cochlea is the part of the inner ear involved in hearing.It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus.
This causes the cell to depolarise, and creates an action potential that is transmitted along the spiral ganglion, which sends information through the auditory portion of the vestibulocochlear nerve to the temporal lobe of the brain. [13] The human ear can generally hear sounds with frequencies between 20 Hz and 20 kHz (the audio range).
The organ of Corti is located in the scala media of the cochlea of the inner ear between the vestibular duct and the tympanic duct and is composed of mechanosensory cells, known as hair cells. [2] Strategically positioned on the basilar membrane of the organ of Corti are three rows of outer hair cells (OHCs) and one row of inner hair cells ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The adult human brain is estimated to contain 86±8 billion neurons, with a roughly equal number (85±10 billion) of non-neuronal cells. [41] Out of these neurons, 16 billion (19%) are located in the cerebral cortex, and 69 billion (80%) are in the cerebellum.
In lepidosaurs, the hearing organ, the basilar papilla, is generally small, with at most 2000 hair cells, whereas in archosaurs the basilar papilla can be much longer (>10mm in owls) and contain many more hair cells that show two typical size extremes, the short and the tall hair cells. In mammals, the structure is known as the organ of Corti ...