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Zoledronic acid is used to prevent bone fractures in patients with cancers such as multiple myeloma and prostate cancer, as well as for treating osteoporosis. [10] It can also be used to treat hypercalcaemia of malignancy and can be helpful for treating pain from bone metastases.
This includes multiple myeloma in those who have and have not previously received treatment. [3] It is generally used together with other medications. [3] It is given by injection. [4] Common side effects include nausea, diarrhea, tiredness, low platelets, fever, numbness, low white blood cells, shortness of breath, rash and abdominal pain. [4]
A 2016 study concluded that stem cell transplant is the preferred treatment for multiple myeloma. [107] There are two types of stem cell transplants to treat multiple myeloma. [108] In autologous hematopoietic stem-cell transplantation (ASCT) – the patient's stem cells are collected from the patient's blood. The patient is given high-dose ...
[33] [34] In May 2016 daratumumab was also conditionally approved by the European Medicines Agency for treatment of multiple myeloma. [35] In November 2016, the FDA approved daratumumab in combination with lenalidomide or bortezomib and dexamethasone for the treatment of people with multiple myeloma who have received at least one prior therapy ...
For multiple myeloma, it is a first line treatment, and is given with dexamethasone. [8] It is taken by mouth. [8] Common side effects include diarrhea, itchiness, joint pain, fever, headache, and trouble sleeping. [8] Severe side effects include low blood platelets, low white blood cells, and blood clots. [8]
In some cases they are often used at lower doses, which means that the side effects are minimized, [166] while in other cases doses similar to ones used to treat cancer are used. Methotrexate is used in the treatment of rheumatoid arthritis (RA), [167] psoriasis, [168] ankylosing spondylitis [169] and multiple sclerosis.
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