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nQuery is a clinical trial design platform used for the design and monitoring of adaptive, group sequential, and fixed sample size trials. It is most commonly used by biostatisticians to calculate sample size and statistical power for adaptive clinical trial design. nQuery is proprietary software developed and distributed by Statsols. The ...
The P program can be used for studies with dichotomous, continuous, or survival response measures. The user specifies the alternative hypothesis in terms of differing response rates, means, survival times, relative risks, or odds ratios. Matched or independent study designs may be used.
Predictive probability of success (PPOS) is a statistics concept commonly used in the pharmaceutical industry including by health authorities to support decision making. In clinical trials, PPOS is the probability of observing a success in the future based on existing data. It is one type of probability of success.
The probability density function (PDF) for the Wilson score interval, plus PDF s at interval bounds. Tail areas are equal. Since the interval is derived by solving from the normal approximation to the binomial, the Wilson score interval ( , + ) has the property of being guaranteed to obtain the same result as the equivalent z-test or chi-squared test.
CPOS is an extension of conditional power. Its success criteria are not restricted to statistical significance. However when the success is defined as statistical significance, it becomes conditional power. Predictive probability of success (PPOS): It is the probability of observing success in the future given the observed data. PPOS is an ...
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Factorial experimental design software drastically simplifies previously laborious hand calculations needed before the use of computers. During World War II, a more sophisticated form of DOE, called factorial design, became a big weapon for speeding up industrial development for the Allied forces. These designs can be quite compact, involving a
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