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Because medications have been linked to approximately 22% to 28% of all cases of dysgeusia, researching a treatment for this particular cause has been important. [39] Xerostomia, or a decrease in saliva flow, can be a side effect of many drugs, which, in turn, can lead to the development of taste disturbances such as dysgeusia. [39]
Dysgeusia (usually a bitter or metallic taste) is present in about 60% of people with BMS, a factor which led to the concept of a defect in sensory peripheral neural mechanisms. [12] Changes in the oral environment, such as changes in the composition of saliva, may induce neuropathy or interruption of nerve transduction.
In some people, daily use of amiodarone at 100 mg oral doses can be effective for arrhythmia control with no or minimal side effects. [36] Some common side effects include: nausea and vomiting; [13] taste disturbances (changes in taste perception, often described as a metallic or bitter taste in the mouth); [13]
The most common side effects in the absence of alcohol are headache, and a metallic or garlic taste in the mouth, though more severe side effects may occur. [10] Tryptophol, a chemical compound that induces sleep in humans, is formed in the liver after disulfiram treatment. [11]
A common side effect is taste changes, especially a metallic taste, occurring in between 1 in 10 and 1 in 100 treated patients. [60] It has a maximum dose of 200 mg on each occasion according to the SPC, but it has been given in doses of 500 mg. Doses can be given up to 3 times a week. [61]
Over 400 medications are associated with xerostomia. [8] Although drug induced xerostomia is commonly reversible, the conditions for which these medications are prescribed are frequently chronic. [8] The likelihood of xerostomia increases in relation to the total number of medications taken, whether the individual medications are xerogenic or ...
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Some report a metallic taste in the mouth. [4] On neurological examination, the weakness demonstrated with normal testing of power is often less severe than would be expected on the basis of the symptoms. Strength improves further with repeated testing, e.g. improvement of power on repeated hand grip (a phenomenon known as "Lambert's sign").