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As a result of cholinergic crisis, the muscles stop responding to the high synaptic levels of ACh, leading to flaccid paralysis, respiratory failure, and other signs and symptoms reminiscent of organophosphate poisoning. Other symptoms include increased sweating, salivation, bronchial secretions along with miosis (constricted pupils).
Toxic encephalopathy is a neurologic disorder caused by exposure to neurotoxic organic solvents such as toluene, following exposure to heavy metals such as manganese, as a side effect of melarsoprol treatment for African trypanosomiasis, adverse effects to prescription drugs, or exposure to extreme concentrations of any natural toxin such as cyanotoxins found in shellfish or freshwater ...
Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins).Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the central nervous system of mammals. [14]
As a result, this memory favoring pathway is stopped, and the brain loses essential memory function. The loss of memory is a symptom of neurodegenerative disease , including AD. Another way Aβ causes cell death is through the phosphorylation of AKT ; this occurs as the phosphate group is bound to several sites on the protein.
Fear or anxiety that leads to a panic attack can cause shivering or chills. Cohan says feeling anxious or scared activates your body’s fight-or-flight response, triggering the release of ...
Effects on the body include weakness and mild-to-moderate dehydration from the severe anxiety and both blood and sweat loss. [9] The condition is very rare, but there are reports in the medical literature of successful treatment with beta blockers (propranolol 10 mg), [10] [11] with significant reduction in the frequency of spontaneous blood ...
During a panic attack, the body's stress response is triggered which can cause the small vessels of the heart to tighten, leading to chest pain. The body's nervous system and rapid breathing during a panic attack can cause spasming of the arteries of the heart (also known as vasospasm). This can reduce blood flow to the heart, causing damage to ...
Symptoms include miosis, sweating, lacrimation, gastrointestinal symptoms, respiratory difficulties, shortness of breath, slowed heart rate, cyanosis, vomiting, diarrhea, trouble sleeping, as well as other symptoms. Along with these central effects can be seen and finally seizures, convulsions, coma, respiratory failure.
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