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Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. This means models can be ...
The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease. [ 2 ] The Mouse Models of Human Cancer database (MMHCdb) is a unique, comprehensive online knowledgebase of mouse models of human cancer hosted by The Jackson Laboratory ...
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. [ 1 ] 4T1 cells are epithelial and are resistant to 6-thioguanine . [ 1 ] In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.
The organ tropism of patient-derived CTC has been investigated in a mouse model. [88] CTCs isolated from breast cancer patients and expanded in vitro showed they could generate bone, lung, ovary and brain metastases in mice, partially reflecting the secondary lesions as found in the corresponding patients. Remarkably, one CTC line—isolated ...
Mouse models of breast cancer metastasis Metadata This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
Other studies have found that the prognosis of MBC, similar to female breast cancer: depends on their cancer's TNM stage; that stage for stage, the prognoses of MBC appears similar to that in female breast cancer; and that MBC has a somewhat lower 5-year overall survival rate than female breast cancer (82.8% vs. 88.5%, respectively). [21]
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Male cats may also develop mammary adenocarcinoma, albeit rarely, and the clinical course is similar to female cats. [22] As in dogs, tumor size is an important prognostic factor, although for tumors less than three centimeters the individual size is less predictive.