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A new Mass General Brigham study links high doses of prescription amphetamines such as Adderall to a risk of psychosis and mania. ... Although the side effects of the drug are a rarity, study lead ...
Recent research has found that high-dose prescription amphetamines, ... There are a number of potential side effects to taking amphetamines, ... “This is a rare but serious side effect that ...
Drugs in the class of amphetamines, or substituted amphetamines, are known to induce "amphetamine psychosis" typically when chronically abused or used in high doses. [8] In an Australian study of 309 active methamphetamine users, 18% had experienced a clinical level psychosis in the past year. [9]
Taking a high dose of ADHD drugs is linked to more than five times greater risk of developing psychosis or mania, according to a new study published Thursday in the American Journal of Psychiatry.
Long-term amphetamine exposure at sufficiently high doses in some animal species is known to produce abnormal dopamine system development or nerve damage, [38] [39] but, in humans with ADHD, long-term use of pharmaceutical amphetamines at therapeutic doses appears to improve brain development and nerve growth.
Very high doses can result in psychosis (e.g., hallucinations, delusions and paranoia) which rarely occurs at therapeutic doses even during long-term use. Recreational doses are generally much larger than prescribed therapeutic doses and carry a far greater risk of serious side effects. [sources 3] Amphetamine belongs to the phenethylamine class.
In this study, “high dosage” referred to 30 milligrams (mg) or more of amphetamines. The researchers also concluded that people taking any prescription amphetamine had a 63% higher risk of ...
The effects of amphetamine on gene regulation are both dose- and route-dependent. [134] Most of the research on gene regulation and addiction is based upon animal studies with intravenous amphetamine administration at very high doses. [134]