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  2. Evolution of ageing - Wikipedia

    en.wikipedia.org/wiki/Evolution_of_ageing

    The somatic mutation theory of ageing states that accumulation of mutations in somatic cells is the primary cause of aging. A comparison of somatic mutation rate across several mammal species found that the total number of accumulated mutations at the end of lifespan was roughly equal across a broad range of lifespans. [16]

  3. Mutation accumulation theory - Wikipedia

    en.wikipedia.org/wiki/Mutation_accumulation_theory

    The mutation accumulation theory of aging was first proposed by Peter Medawar in 1952 as an evolutionary explanation for biological aging and the associated decline in fitness that accompanies it. [1] Medawar used the term 'senescence' to refer to this process.

  4. DNA damage theory of aging - Wikipedia

    en.wikipedia.org/wiki/DNA_damage_theory_of_aging

    A related theory is that mutation, as distinct from DNA damage, is the primary cause of aging. A comparison of somatic mutation rate across several mammal species found that the total number of accumulated mutations at the end of lifespan was roughly equal across a broad range of lifespans. [49]

  5. Genetics of aging - Wikipedia

    en.wikipedia.org/wiki/Genetics_of_aging

    Genetics of aging is generally concerned with life extension associated with genetic alterations, rather than with accelerated aging diseases leading to reduction in lifespan. The first mutation found to increase longevity in an animal was the age-1 gene in Caenorhabditis elegans .

  6. Antagonistic pleiotropy hypothesis - Wikipedia

    en.wikipedia.org/wiki/Antagonistic_pleiotropy...

    Strength of natural selection plot as a function of age. The antagonistic pleiotropy hypothesis (APT) is a theory in evolutionary biology that suggests certain genes may confer beneficial effects early in an organism's life, enhancing reproductive success, while also causing detrimental effects later in life, contributing to the aging process.

  7. Disposable soma theory of aging - Wikipedia

    en.wikipedia.org/.../Disposable_soma_theory_of_aging

    The disposable soma theory of aging posits that there is a trade-off in resource allocation between somatic maintenance and reproductive investment.Too low an investment in self-repair would be evolutionarily unsound, as the organism would likely die before reproductive age.

  8. Biogerontology - Wikipedia

    en.wikipedia.org/wiki/Biogerontology

    Environmental factors and genetic mutations can influence gene expression and accelerate aging. More recently epigenetics have been explored as a contributing factor. The epigenetic clock , which relatively objectively measures the biological age of cells, are useful tool for testing different anti-aging approaches. [ 34 ]

  9. Hayflick limit - Wikipedia

    en.wikipedia.org/wiki/Hayflick_limit

    Hayflick interpreted his discovery to be aging at the cellular level. The aging of cell populations appears to correlate with the overall physical aging of an organism. [3] [4] Macfarlane Burnet coined the name "Hayflick limit" in his book Intrinsic Mutagenesis: A Genetic Approach to Ageing, published in 1974. [5]