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Pharmaceutical-grade PEG is used as an excipient in many pharmaceutical products, in oral, topical, and parenteral dosage forms. [4]PEG is the basis of a number of laxatives (as MiraLax, RestoraLAX, MoviPrep, etc.). [5]
Macrogol is used as an excipient in pharmaceutical products. [4] Lower-molecular-weight variants are used as solvents in oral liquids and soft capsules, whereas solid variants are used as ointment bases, tablet binders, film coatings, and lubricants. [21] For example, PEG-2000 is one of the excipients in the Moderna COVID-19 vaccine. [22] [23]
PEG 400 (polyethylene glycol 400) is a low-molecular-weight grade of polyethylene glycol. It is a clear, colorless, viscous liquid. Due in part to its low toxicity, PEG 400 is widely used in a variety of pharmaceutical formulations.
The approximate lengths of the two PEG blocks is 101 repeat units, while the approximate length of the propylene glycol block is 56 repeat units. [1] This particular compound is also known by the BASF trade name Pluronic F-127 or by the Croda trade name Synperonic PE/F 127. BASF also offers a pharmaceutical grade, under trade name Kolliphor P ...
Polyethylene glycol. PEGylation (or pegylation) is the process of both covalent and non-covalent attachment or amalgamation of polyethylene glycol (PEG, in pharmacy called macrogol) polymer chains to molecules and macrostructures, such as a drug, therapeutic protein or vesicle, which is then described as PEGylated.
Polyethylene glycol–polyvinyl alcohol (PEG-PVA) brand name Kollicoat IR is a multifunctional excipient [1] used as a pill binder as well as a wet binder. A typical formulation is composed of 25% polyethylene glycol (PEG) and 75% polyvinyl alcohol (PVA); where the vinyl alcohol moieties are grafted on a polyethylene glycol backbone.
The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. [11] In Australia, it is only allowed at less than 0.25% w/w of DEG as an impurity in polyethylene glycol (PEG), [12] even in toothpaste. [13]
Polyethylene glycol propylene glycol cocoates or PEG propylene glycol cocoates are chemical compounds produced by the esterification of polyoxyalkyl alcohols with fatty acids from coconut oil (primarily lauric acid). [1] Their chemical designation is PEG-8, [2] referring to its polyethylene glycol (PEG) molecular chain length.
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