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Leptospirosis is a blood infection caused by the bacterium Leptospira [8] that can infect humans, dogs, rodents and many other wild and domesticated animals. [8] Signs and symptoms can range from none to mild ( headaches , muscle pains , and fevers ) to severe ( bleeding in the lungs or meningitis ). [ 5 ]
In particular, L. interrogans cells survive and multiply at an optimal rate in the kidneys. The pathogen mostly spreads through the bodily fluids of infected animals. [17] Rats are the primary carrier of leptospirosis but do not present any symptoms, transmitting the pathogen through urine, which is able to persist in freshwater. [27]
An unusual feature of leptospiral LPS is that it activates host cells via TLR2 rather than TLR4. [27] The unique structure of the lipid A portion of the LPS molecule may account for this observation. [28] Finally, the LPS O antigen content of L. interrogans differs in an acutely infected versus a chronically infected animal. [29]
A spirochaete (/ ˈ s p aɪ r oʊ ˌ k iː t /) [4] or spirochete is a member of the phylum Spirochaetota (also called Spirochaetes [5] / ˌ s p aɪ r oʊ ˈ k iː t iː z /), which contains distinctive diderm (double-membrane) Gram-negative bacteria, most of which have long, helically coiled (corkscrew-shaped or spiraled, hence the name) cells ...
Cells are able to be of the same genotype but of different cell type due to the differential expression of the genes they contain. Most distinct cell types arise from a single totipotent cell, called a zygote, that differentiates into hundreds of different cell types during the course of development.
The list of organisms by chromosome count describes ploidy or numbers of chromosomes in the cells of various plants, animals, protists, and other living organisms.This number, along with the visual appearance of the chromosome, is known as the karyotype, [1] [2] [3] and can be found by looking at the chromosomes through a microscope.
Leptospira noguchii is another pathogenic bacteria that causes Leptospirosis. Leptospirosis can be transferred in a multitude of ways. Leptospirosis can transfer from animals to humans , humans to humans, or animals to animals via intake of contaminated body fluids, such as urine and blood. [7]
To avoid antibodies attacking it, the cell has few proteins exposed on the outer membrane sheath. [52] Its chromosome is about 1000 kilobase pairs and is circular with a 52.8% G + C average. [ 43 ] Sequencing has revealed a bundle of 12 proteins and some putative hemolysins are potential virulence factors of T. pallidum. [ 53 ]