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The ACTH test (also called the cosyntropin, tetracosactide, or Synacthen test) is a medical test usually requested and interpreted by endocrinologists to assess the functioning of the adrenal glands' stress response by measuring the adrenal response to adrenocorticotropic hormone (ACTH; corticotropin) or another corticotropic agent such as tetracosactide (cosyntropin, tetracosactrin; Synacthen ...
Adrenocorticotropic hormone is used as a medication and as diagnostic agent in the ACTH stimulation test. [ 1 ] [ 2 ] : 316, 1165 [ 3 ] : 84, 271 The form that is purified from pig pituitary glands is known as corticotropin [ 1 ] [ 2 ] : 316 is a medication and naturally occurring polypeptide tropic hormone produced and secreted by the anterior ...
A low-dose ACTH stimulation test has been suggested as a sensitive test for secondary adrenal insufficiency diagnosis. [10] When compared to insulin tolerance testing [11] and the high-dose ACTH test, this test allows for a more accurate identification of patients with secondary adrenal insufficiency. [12]
Urinary free cortisol can also be measured, but are not necessary for diagnosis. [2] To determine the origin of dysfunction, the ACTH stimulation test is the best initial test as it can differentiate between primary and secondary adrenal insufficiency. [2]
It is possible to test for heterozygosity by measuring 17OHP elevation after ACTH stimulation. [139] More than 200 disease-causing variants within the CYP21A2 gene have been identified so far that lead to 21-hydroxylase deficiency. [140] Most patients have at least two of these variants present as compound heterozygous. [141] [142] [143]
Inefficient cortisol production results in rising levels of ACTH, because cortisol feeds back to inhibit ACTH production, so loss of cortisol results in increased ACTH. [28] This increased ACTH stimulation induces overgrowth (hyperplasia) and overactivity of the steroid-producing cells of the adrenal cortex. The defects causing adrenal ...
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by increased plasma angiotensin II, ACTH, or potassium levels. The ACTH stimulation test is sometimes used to stimulate the production of aldosterone along with cortisol to determine if primary or secondary adrenal insufficiency is present. by plasma acidosis. by the stretch receptors located in the atria of the heart.
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