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Maleic anhydride is a classic substrate for Diels-Alder reactions. [9] It was used for work in 1928, on the reaction between maleic anhydride and 1,3-butadiene, for which Otto Paul Hermann Diels and Kurt Alder were awarded the Nobel Prize in 1950. It is through this reaction that maleic anhydride is converted to many pesticides and pharmaceuticals.
In industry, maleic acid is derived by hydrolysis of maleic anhydride, the latter being produced by oxidation of benzene or butane. [4] Maleic acid is an industrial raw material for the production of glyoxylic acid by ozonolysis. [8] Maleic acid may be used to form acid addition salts with drugs to make them more stable, such as indacaterol ...
Maleimide-mediated methodologies are among the most used in bioconjugation. [5] [6] Due to fast reactions and high selectivity towards cysteine residues in proteins, a large variety of maleimide heterobifunctional reagents are used for the preparation of targeted therapeutics, assemblies for studying proteins in their biological context, protein-based microarrays, or proteins immobilisation. [7]
2,3-Dimethylmaleic anhydride is an organic compound with the formula (CH 3) 2 C 2 (CO) 2 O. [1] It is related to maleic anhydride (MA) by replacement of the two CH units with CCH 3 groups. The compound can be prepared from two eqiuvalents of MA in the presence of 2-aminopyridine followed by treatment with sulfuric acid.
In another process, maleic anhydride is first opened with water or another alcohol to form maleic acid and is then reacted with DCPD where an alcohol from the maleic acid reacts across one of the double bonds of the DCPD. This product is then used to end-cap the UPR resin which yields a product with unsaturation on the end-groups.
Styrene maleic anhydride (SMA or SMAnh) is a synthetic polymer that is built-up of styrene and maleic anhydride monomers. In one copolymer , the monomers can be almost perfectly alternating. [ 1 ] but (random) copolymerisation with less than 50% maleic anhydride content is also possible. [ 2 ]
The reaction proceeds with about 70% selectivity. About 10% of maleic anhydride is also produced: C 6 H 4 (CH 3) 2 + 7 + 1 / 2 O 2 → C 4 H 2 O 3 + 4 H 2 O + 4 CO 2. Phthalic anhydride and maleic anhydride are recovered by distillation by a series of switch condensers.
The following other wikis use this file: Usage on ar.wikipedia.org أنهيدريد المالييك; Usage on de.wikipedia.org Maleinsäureanhydrid