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A pi stacking interaction between tacrine (blue) and Trp84 (red) is proposed. Pi stacking is prevalent in protein crystal structures, and also contributes to the interactions between small molecules and proteins. As a result, pi–pi and cation–pi interactions are important factors in rational drug design. [24]
π–π stacking is a noncovalent interaction between the pi bonds of aromatic rings. [12] Such "sandwich interactions" are however generally electrostatically repulsive. What is more commonly observed are either a staggered stacking (parallel displaced) or pi-teeing (perpendicular T-shaped) interaction both of which are electrostatic ...
Cation–π interaction between benzene and a sodium cation. Cation–π interaction is a noncovalent molecular interaction between the face of an electron-rich π system (e.g. benzene, ethylene, acetylene) and an adjacent cation (e.g. Li +, Na +). This interaction is an example of noncovalent bonding between a monopole (cation) and a ...
π–π interactions are associated with the interaction between the π-orbitals of a molecular system. [3] The high polarizability of aromatic rings lead to dispersive interactions as major contribution to so-called stacking effects. These play a major role for interactions of nucleobases e.g. in DNA. [19]
In chemistry, π-effects or π-interactions are a type of non-covalent interaction that involves π systems.Just like in an electrostatic interaction where a region of negative charge interacts with a positive charge, the electron-rich π system can interact with a metal (cationic or neutral), an anion, another molecule and even another π system. [1]
Propidium iodide (or PI) is a fluorescent intercalating agent that can be used to stain cells and nucleic acids. PI binds to DNA by intercalating between the bases with little or no sequence preference. When in an aqueous solution, PI has a fluorescent excitation maximum of 493 nm (blue-green), and an emission maximum of 636 nm (red).
Deoxyribozymes, also called DNA enzymes, DNAzymes, ... to just three types of interactions: hydrogen bonding, pi stacking, and metal-ion coordination.
Molecular self-assembly is a key concept in supramolecular chemistry. [6] [7] [8] This is because assembly of molecules in such systems is directed through non-covalent interactions (e.g., hydrogen bonding, metal coordination, hydrophobic forces, van der Waals forces, pi-stacking interactions, and/or electrostatic) as well as electromagnetic interactions.