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Oral oxycodone has a half-life of 4.5 hours. [89] It is available as a generic medication. [16] ... Canadian oxycodone HCL/acetaminophen 5/325 mg tablet.
MST Continus is a 12-hour release formula, therefore it is given 2 times per day. It is available in the following doses: 5 mg, 10 mg, 15 mg, 30 mg, 60 mg, 100 mg and 200 mg tablets (equating to between 0.416 mg/hour and 16.67 mg/hour).
Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. [6]
10 mg Oxycodone: PO: 20 mg Oxycodone: IV: 20 mg Oxymorphone: PO: 10 mg Oxymorphone: IV: 1 mg ... The elimination half-life of morphine is approximately 120 min ...
For example, the narcotic levorphanol is 4–8 times stronger than morphine, but also has a much longer half-life. Simply switching the patient from 40 mg of morphine to 10 mg of levorphanol would be dangerous due to dose accumulation, and hence frequency of administration should also be taken into account.
Oral hydrocodone has a mean equivalent daily dosage (MEDD) factor of 0.4, meaning that 1 mg of hydrocodone is equivalent to 0.4 mg of intravenous morphine. However, because of morphine's low oral bioavailability , there is a 1:1 correspondence between orally administered morphine and orally administered hydrocodone.
The typical half-life of intravenous hydromorphone is 2.3 hours. [48] Peak plasma levels usually occur between 30 and 60 minutes after oral dosing. [49] The onset of action for hydromorphone administered intravenously is less than 5 minutes and within 30 minutes of oral administration (immediate release). [39]
20 mg Oxycodone: IV: 10 mg Oxymorphone: PO: 10 mg Oxymorphone: IV: 1 mg Codeine is a nonsynthetic opioid. [32] ... Plasma half life is between 3 and 4 hours, and oral ...