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  2. Cytokine-induced killer cell - Wikipedia

    en.wikipedia.org/wiki/Cytokine-induced_killer_cell

    Cytokine-induced killer cells (CIK) cells are a group of immune effector cells featuring a mixed T- and natural killer (NK) cell-like phenotype.They are generated by ex vivo incubation of human peripheral blood mononuclear cells (PBMC) or cord blood mononuclear cells with interferon-gamma (), anti-CD3 antibody, recombinant human interleukin (IL)-1 and recombinant human interleukin (IL)-2.

  3. Cytokine delivery systems - Wikipedia

    en.wikipedia.org/wiki/Cytokine_delivery_systems

    RPE cells are ideal cytokine delivery systems because they are nontumorigenic, display contact inhibition, are amenable to genetic modification, have bene previously used in human trials for therapeutic delivery systems, and are safe to use. [3] RPE cells engineered to produce different cytokines were encapsulated in alginate-based microparticles.

  4. Cytotoxic T cell - Wikipedia

    en.wikipedia.org/wiki/Cytotoxic_T_cell

    Antigen presentation stimulates T cells to become either "cytotoxic" CD8+ cells or "helper" CD4+ cells.. A cytotoxic T cell (also known as T C, cytotoxic T lymphocyte, CTL, T-killer cell, cytolytic T cell, CD8 + T-cell or killer T cell) is a T lymphocyte (a type of white blood cell) that kills cancer cells, cells that are infected by intracellular pathogens such as viruses or bacteria, or ...

  5. T helper cell - Wikipedia

    en.wikipedia.org/wiki/T_helper_cell

    In order to create sufficient auto-reactive killer T cells, interleukin-2 must be produced, and this is supplied by CD4 + T cells. CD4 + T cells can also stimulate cells such as natural killer cells and macrophages via cytokines such as interferon-gamma, encouraging these cytotoxic cells to kill host cells in certain circumstances.

  6. Natural killer T cell - Wikipedia

    en.wikipedia.org/wiki/Natural_killer_T_cell

    The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses. Most clinical trials with NKT cells have been performed with cytokine-induced killer cells (CIK). [16]

  7. Natural killer cell - Wikipedia

    en.wikipedia.org/wiki/Natural_killer_cell

    Tumor cell detection results in activation of NK cells and consequent cytokine production and release. If tumor cells do not cause inflammation, they will also be regarded as self and will not induce a T cell response. A number of cytokines are produced by NKs, including tumor necrosis factor α , IFNγ, and interleukin . TNFα and IL-10 act as ...

  8. Interleukin-1 family - Wikipedia

    en.wikipedia.org/wiki/Interleukin-1_family

    Cytokine-induced effector cytokine production [ edit ] IL-33 has a role in so called cytokine-induced effector cytokine production, which means that a production of effector cytokines by differentiated T helper lymphocytes is cytokine dependent and can happen without antigen stimulation by T-cell receptor of these cells.

  9. Cell-mediated immunity - Wikipedia

    en.wikipedia.org/wiki/Cell-mediated_immunity

    It has been found in both mice and humans that the signature cytokines for these cells are interferon gamma and lymphotoxin alpha. The main cytokine for differentiation into T H 1 cells is IL-12 which is produced by dendritic cells in response to the activation of pattern recognition receptors. T-bet is a distinctive transcription factor of T H ...

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