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Naltrexone/bupropion, sold under the brand name Contrave among others, is a fixed-dose combination medication for the management of chronic obesity in adults in combination with a reduced-calorie diet and increased physical activity. [4] [6] It contains naltrexone, an opioid antagonist, and bupropion, an aminoketone atypical antidepressant. [4]
Bupropion, when used for treating long-term weight gain over six to twelve months, results in an average weight loss of 2.7 kilograms (6.0 lb) over placebo. [74] This is not much different from the weight loss produced by several other weight-loss medications such as sibutramine or orlistat . [ 74 ]
Regular physical activity can help accelerate weight loss, improve metabolism and enhance the benefits of weight loss pills. Aim for 150 minutes per week (or about a half-hour five days a week).
Alternatively, switching from a more modern type of antidepressant, such as an SSRI or SNRI, to an antidepressant for weight loss, such as bupropion, may also produce improvements.
Typically, the recommended starting dosage for Wellbutrin is 200mg per day, with a maximum dosage of 450mg per day. The starting dosage is taken as 100mg twice per day.
Vyvanse (lisdexamfetamine) – a pro-drug stimulant used to treat attention deficit hyperactivity disorder and binge eating disorder; Vyvanse is converted into Dexedrine in vivo; Viibryd – an antidepressant of the serotonin modulator and stimulators class; Vivactil (protriptyline) an antidepressant also used in the treatment of nerve pain
The medications liraglutide, [4] naltrexone/bupropion, [5] orlistat, [6] semaglutide, [7] and tirzepatide [8] are approved by the US Food and Drug Administration (FDA) for weight management in combination with reduced-calorie diet and increased physical activity.
The saying “knowledge is power” applies well in certain situations — like becoming a leader in your field of expertise or knowing the best places to eat (we all have different skills).