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Dantrolene sodium, sold under the brand name Dantrium among others, is a postsynaptic muscle relaxant that lessens excitation-contraction coupling in muscle cells. [ 5 ] [ 6 ] [ 7 ] It achieves this by inhibiting Ca 2+ ions release from sarcoplasmic reticulum stores by antagonizing ryanodine receptors . [ 8 ]
Dantrolene, although thought of primarily as a peripherally acting agent, is associated with CNS effects, whereas baclofen activity is strictly associated with the CNS. Muscle relaxants are thought to be useful in painful disorders based on the theory that pain induces spasm and spasm causes pain.
Baclofen, diazepam and dantrolene remain the three most commonly used pharmacologic agents in the treatment of spastic hypertonia. Baclofen is generally the drug of choice for spinal cord types of spasticity, while sodium dantrolene is the only agent which acts directly on muscle tissue. Tizanidine is also available.
Oral medications used for the treatment of spasticity include: diazepam (Valium), dantrolene sodium, baclofen, tizanidine, clonidine, gabapentin, [59] [61] [62] and even cannabinoid-like compounds.³ The exact mechanism of these medications is not fully understood, but they are thought to act on neurotransmitters or neuromodulators within the ...
Drugs such as baclofen, benzodiazepines (e.g., diazepam), tizanidine, and sometimes dantrolene have shown promise in the effort to diminish spasticity. [10] Botulinum toxin ("Botox") type A may reduce spasticity a few months at a time and has frequently been considered a beneficial treatment for children with SHCP and other forms of CP. [5]
You've likely seen warnings against taking aspirin as a preventative measure against heart attack and stroke. It isn't quite that simple.
Researchers are now proposing a surprising location for the birthplace of dinosaurs, based on the locations of the currently oldest-known dinosaur fossils, the evolutionary relationships among ...
A general treatment guideline can be followed that involves: [23] The initial focus on first activating contraction of antagonist muscles to provide reciprocal inhibition and lengthen spastic muscles; Reciprocal actions are attempted. Agonist contractions are performed first in small ranges progressing to larger arcs of movement
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