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Hence, 4-AcO-DMT results in modestly lower psilocin levels than psilocybin even when the drugs are given at equivalent doses with adjustment for differences in molecular weight. [2] Along similar lines, the psilocin concentrations with 4-AcO-DMT 15 minutes after administration were 75 to 90% of those of an equimolar dose of psilocybin. [2]
In June 2024, the Food and Drug Administration (FDA) reported that it had identified 4-AcO-DMT, a synthetic and unscheduled psychedelic drug related to psilocybin (4-PO-DMT; the active component of psilocybin mushrooms), [11] in Diamond Shruumz products. [2] [3] Both 4-AcO-DMT and psilocybin are prodrugs of the serotonergic psychedelic psilocin.
[12] [13] [14] [2] Both psilocybin and 4-AcO-DMT are prodrugs of the serotonergic psychedelic psilocin. [1] [15] [2] [11] Psychedelic mushroom stores operate in a legal grey area and the products sold by these stores may be either illegal controlled substances (e.g., psilocybin mushrooms, psilocybin) or legal (e.g., Amanita muscaria mushrooms ...
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
4-HO-5-MeO-DMT (psilomethoxin) mushrooms derived from Psilocybe cubensis mycelium in substrate with added 5-MeO-DMT. [1] [2] 4-HO-DET and 4-PO-DET mushrooms derived from Psilocybe cubensis mycelium in substrate with added DET. [3] [4] 4-HO-DiPT mushrooms derived from Psilocybe cubensis mycelium in substrate with added DiPT. [2] 4-HO-DPT ...
Some synthetic substances like 4-AcO-DMT are thought to be prodrugs that metabolize into psychoactive substances that have been used as entheogens. While synthetic DMT and mescaline are reported to have identical entheogenic qualities as extracted or plant-based sources, the experience may wildly vary due to the lack of numerous psychoactive ...
Psilacetin (O-acetylpsilocin; 4-AcO-DMT) – non-selective serotonin receptor agonist and psychedelic hallucinogen – substance-related disorders – Psilera [180] Psilocin (PLZ-1015) – non-selective serotonin receptor agonist and psychedelic hallucinogen – pervasive child development disorders – Pilz Bioscience [181]
In rodents, 4-HO-TMT showed no head-twitch response (a behavioral proxy of psychedelic effects), hypolocomotion, or hypothermia, in contrast to psilocin and norpsilocin, but similarly to aeruginascin. [3] A synthetic prodrug of 4-HO-TMT, 4-AcO-TMT, has been developed. [1] [5] It is analogous to psilacetin (4-AcO-DMT), a prodrug of psilocin. [1] [5]