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Methylphenidate is used for the treatment of attention deficit hyperactivity disorder (ADHD). [30] The dosage may vary and is titrated to effect, with some guidelines recommending initial treatment with a low dose. [31] Methylphenidate is available in both immediate-release and modified-release formulations to provide a sustained release of the ...
Despite having a similar therapeutic mechanism of action as first-line medications containing amphetamine, the prescription of dextromethamphetamine for ADHD is rare due its relatively greater reinforcing potential, in addition to the comparable efficacy and presumably greater safety of methylphenidate and amphetamine.
The study evaluated three types of prescription amphetamines: mixed prescription amphetamines, such as Adderall and Mydayis, dextroamphetamine and lisdexamfetamine, which is sold under the brand ...
One in four U.S. adults suspects they may have ADHD and drugs are a first line of treatment for this condition. But what does research say about their impact on the brain and quality of life?
A systematic review and meta-analysis from 2019 assessed the efficacy of 17 different pharmacotherapies used in randomized controlled trials (RCTs) for amphetamine and methamphetamine addiction; [147] it found only low-strength evidence that methylphenidate might reduce amphetamine or methamphetamine self-administration. [147]
Amphetamines and methylphenidate are classified by the Drug Enforcement Administration as Schedule II controlled substances, the same designation given to cocaine, OxyContin and fentanyl.
Because some adverse effects may only emerge during chronic use of methylphenidate, a constant watch for adverse effects is recommended. [30] A 2018 Cochrane review found that methylphenidate might be associated with serious side effects such as heart problems, psychosis, and death. The certainty of the evidence was stated as very low.
One study reported occurrences at regularly prescribed doses in approximately 0.1% of individuals within the first several weeks after starting amphetamine or methylphenidate therapy. [ 3 ] [ 4 ] [ 5 ] Methamphetamine psychosis, or long-term effects of stimulant use in the brain (at the molecular level), depend upon genetics and may persist for ...
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