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Sterol+Regulatory+Element+Binding+Proteins at the U.S. National Library of Medicine Medical Subject Headings (MeSH) The Brown and Goldstein Lab Archived 2009-05-26 at the Wayback Machine. Cholesterol Synthesis Archived 2017-07-04 at the Wayback Machine - has some good regulatory details; Protein Data Base (PDB), Sterol Regulatory Element ...
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by the SREBF1 gene. [5] [6] This gene is located within the Smith–Magenis syndrome region on chromosome 17.
235623 Ensembl ENSG00000114650 ENSMUSG00000032485 UniProt Q12770 Q6GQT6 RefSeq (mRNA) NM_012235 NM_001320044 NM_001001144 NM_001103162 RefSeq (protein) NP_001306973 NP_036367 NP_001001144 NP_001096632 Location (UCSC) Chr 3: 47.41 – 47.48 Mb Chr 9: 110.16 – 110.21 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Sterol regulatory element-binding protein cleavage-activating protein ...
The main regulatory mechanism is the sensing of intracellular cholesterol in the endoplasmic reticulum by the protein SREBP (sterol regulatory element-binding protein 1 and 2). [45] In the presence of cholesterol, SREBP is bound to two other proteins: SCAP (SREBP cleavage-activating protein) and INSIG-1.
Several key enzymes can be activated through DNA transcriptional regulation on activation of SREBP (sterol regulatory element-binding protein-1 and -2). This intracellular sensor detects low cholesterol levels and stimulates endogenous production by the HMG-CoA reductase pathway, as well as increasing lipoprotein uptake by up-regulating the LDL ...
This protein binds to the sterol regulatory element (SRE), located on the 5' end of the reductase gene after controlled proteolytic processing. When SREBP is inactive, it is bound to the ER or nuclear membrane with another protein called SREBP cleavage-activating protein (SCAP). SCAP senses low cholesterol concentration and transports SREBP to ...
The actions of this protein are influenced by small molecules such as glucose and fructose. The amount of glucokinase can be increased by synthesis of new protein. Insulin is the principal signal for increased transcription, operating mainly by way of a transcription factor called sterol regulatory element binding protein-1c (SREBP1c) in the ...
SREBP cleavage-activating protein (SCAP), which regulates transcription of genes with sterol response elements by proteolytically activating sterol regulatory element-binding proteins (SREBPs). This was the second SSD-containing protein to be discovered. 7-dehydrocholesterol reductase (7DHCR), involved in the last step of cholesterol biosynthesis.